Dimethyl Sulfoxide
Apexbio Technology LLC Baricitinib (LY3009104, INCB028050) 1187594-09-7 10mM (in 1mL DMSO)
Baricitinib (LY3009104 INCB028050 CAS 1187594-09-7) is an orally bioavailable ATP-competitive inhibitor targeting Janus kinases JAK1 and JAK2 It also exhibits moderate inhibition of TYK2 and weaker inhibition against JAK3 In biochemical assays baricitinib inhibits JAK1 and JAK2 with IC50 values of 5 9 nM and 5 7 nM respectively At concentrations below 50 nM baricitinib suppresses intracellular signaling mediated by several pro-inflammatory cytokines notably IL-6 and IL-23 Due to its mechanistic profile baricitinib is actively explored in inflammatory disease research such as rheumatoid arthritis
Apexbio Technology LLC AICAR 10mM (in 1mL DMSO)
A8184 is a small molecule developed primarily as a biomedical research tool It functions through modulation of specific cellular signaling pathways implicated in disease states enabling researchers to probe biological targets and cellular mechanisms By influencing these pathways A8184 provides a methodological approach for dissecting cellular responses and clarifying mechanisms involved in pathological conditions This compound is suited for controlled in vitro studies aimed at elucidating disease pathways and evaluating potential therapeutic avenues in biomedical research contexts
Apexbio Technology LLC SP2509 1423715-09-6 10mM (in 1mL DMSO)
SP2509 (CAS 1423715-09-6) is a small molecule antagonist of lysine-specific demethylase 1 (LSD1/KDM1A) a histone-modifying enzyme responsible for demethylating mono- and dimethylated histone H3 lysine 4 (H3K4) SP2509 potently inhibits LSD1 activity (IC50 13 nM) without affecting monoamine oxidase isoforms MAO-A or MAO-B In acute myeloid leukemia (AML) cells SP2509 suppresses LSD1 function reduces colony formation induces apoptosis enhances promoter-specific H3K4 trimethylation and stimulates differentiation through upregulation of p53 p21 and C/EBP Its efficacy has been demonstrated in AML xenograft models supporting its utility as a tool compound for cancer research
Apexbio Technology LLC EPZ015666 1616391-65-1 10mM (in 1mL DMSO)
EPZ015666 (CAS 1616391-65-1) is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) an enzyme implicated in several cellular pathways including tumorigenesis EPZ015666 inhibits PRMT5 with an IC50 of 22 nM and displays a Ki value of approximately 5 nM It exhibits over 20 000-fold selectivity for PRMT5 relative to other protein methyltransferases tested In mantle cell lymphoma (MCL) cell lines treatment with EPZ015666 reduced methylation levels of the PRMT5 substrate SmD3 and exerted concentration-dependent anti-proliferative effects Additionally EPZ015666 demonstrated dose-dependent tumor growth inhibition in mouse xenograft models of MCL highlighting its potential utility as a molecular tool in cancer biology research
Apexbio Technology LLC Linifanib (ABT-869) 796967-16-3 10mM (in 1mL DMSO)
Linifanib (ABT-869 CAS 796967-16-3) is an ATP-competitive inhibitor of receptor tyrosine kinases targeting platelet-derived growth factor (PDGF) and vascular endothelial growth factor receptors (VEGFRs) as well as FMS-like tyrosine kinase 3 (FLT3) including its activating internal tandem duplication (ITD) mutations Linifanib selectively reduces cell growth in FLT3 ITD-expressing cell lines such as Ba/F3 FLT3 ITD cells inhibits phosphorylation of FLT3 and Akt and induces apoptosis preferentially in ITD mutant cells In vivo experiments with ITD-expressing leukemia xenografts show reduced leukemia progression and prolonged survival in mice treated orally with linifanib This compound is widely used in preclinical research for acute myeloid leukemia studies
Apexbio Technology LLC Ondansetron hydrochloride dihydrate 103639-04-9 10mM (in 1mL DMSO)
Ondansetron hydrochloride dihydrate (CAS 103639-04-9) is a small molecule antagonist targeting the serotonin (5-HT3) receptor a ligand-gated ion channel prominent in the central and peripheral nervous systems Through blockade of 5-HT3 receptor signaling ondansetron inhibits serotonin-induced emetic responses Due to this mechanism it is widely utilized in biomedical research investigating serotonin-related signaling pathways and nausea mechanisms particularly in contexts involving chemotherapy-induced emesis
Medchemexpress LLC Docosahexnc Acid 10Mm-1Ml Dmso | HY-B2167-10MM-1ML DMSO
Docosahexnc Acid 10Mm-1Ml Dmso
Apexbio Technology LLC Celastrol 34157-83-0 10mM (in 1mL DMSO)
Celastrol (CAS 34157-83-0) is a triterpene compound isolated from the Chinese medicinal herb Thunder of God Vine It functions as a proteasome inhibitor targeting the proteolytic activities within the 20S and 26S proteasome complexes leading to intracellular accumulation of ubiquitinated substrates including I B- Bax and p27 thereby inducing apoptosis in cancer cell lines such as human prostate cancer (PC-3 and LNCaP) Celastrol also inhibits NF- B signaling decreasing LPS-induced production of inflammatory cytokines (TNF- and IL-1 ) in human PBMCs and augmenting TNF-mediated apoptosis in KBM-5 cells Its anti-inflammatory and pro-apoptotic properties make celastrol relevant in cancer and inflammation research
Apexbio Technology LLC Macitentan 441798-33-0 10mM (in 1mL DMSO)
Macitentan (CAS 441798-33-0) is a small molecule endothelin receptor antagonist acting as a dual inhibitor of ETA and ETB receptors Experimental data using recombinant ETA-expressing CHO cells show that macitentan exhibits potent inhibition of ET-1 ligand binding with an IC50 of approximately 0 5 nM whereas its inhibitory effect on ETB receptors in similar CHO cell systems is weaker (IC50 391 nM) In vivo rodent studies indicate macitentan rapidly converts into ACT-132577 a circulating metabolite with extended half-life and retained dual receptor antagonism This pharmacological profile makes macitentan relevant for biomedical research on endothelin-associated vascular pathologies
Apexbio Technology LLC Verteporfin 129497-78-5 10mM (in 1mL DMSO)
Verteporfin (CAS 129497-78-5) is a porphyrin-derived small molecule used as a photosensitizer in photodynamic therapy (PDT) Upon photoactivation verteporfin induces targeted vascular endothelial cytotoxicity through intravascular damage and thrombosis formation leading to selective vessel closure Experimental studies indicate verteporfin treatment triggers DNA fragmentation and enhances apoptotic events in vitro displaying potent cytotoxicity against HL-60 cells at concentrations around 100 ng/mL Independently of photoactivation verteporfin also directly modifies and inhibits the autophagy adaptor protein p62 impacting its binding to polyubiquitinated substrates Verteporfin is relevant to biomedical research involving PDT mechanisms autophagy pathways and angiogenesis
Apexbio Technology LLC Famprofazone 10mM (in 1mL DMSO)
A8431 is a small molecule that functions as a selective inhibitor of autophagy a conserved cellular pathway responsible for the lysosome-mediated degradation of intracellular components Acting primarily through interference with autophagosome formation or lysosomal fusion A8431 disrupts autophagic flux and thus influences cellular homeostasis and survival pathways It is widely utilized in biomedical research to dissect autophagy-mediated cellular mechanisms and has relevance in studies of cancer biology neurodegeneration and metabolic disorders where autophagy regulation is implicated
Apexbio Technology LLC GSK1838705A 1116235-97-2 10mM (in 1mL DMSO)
GSK1838705A (CAS 1116235-97-2) is a small molecule inhibitor targeting the kinase activity of insulin-like growth factor-1 receptor (IGF-1R) insulin receptor and anaplastic lymphoma kinase (ALK) It exhibits potent inhibition with IC50 values of 2 0 nM for IGF-1R 1 6 nM for insulin receptor and 0 5 nM for ALK In preclinical research GSK1838705A suppresses proliferation of hematologic malignancy-derived tumor cells including multiple myeloma and Ewing sarcoma lines and inhibits tumor xenograft growth in vivo Additionally despite targeting the insulin receptor it minimally affects glucose homeostasis at effective doses Due to its multi-target kinase inhibitory profile GSK1838705A serves as a promising tool for cancer biology research