Dimethyl Sulfoxide
Apexbio Technology LLC LDN193189 Hydrochloride 1062368-62-0 10mM (in 1mL DMSO)
LDN193189 Hydrochloride is a selective pharmacological inhibitor targeting BMP type I receptor kinases specifically activin receptor-like kinase 2 (ALK2) and ALK3 The compound acts by blocking receptor-mediated activation of Smad-dependent signaling pathways (Smad1/5/8 phosphorylation) as well as mitigating associated non-Smad signaling including phosphorylation of Akt and p38 Commonly utilized in biomedical research involving cellular differentiation epithelial barrier integrity and heterotopic ossification LDN193189 has shown the capacity to modulate BMP-induced phenotypic changes in various cell lines such as C2C12 myoblasts and bronchial epithelial cells and to influence related in vivo processes
Apexbio Technology LLC RG7112 939981-39-2 10mM (in 1mL DMSO)
RG7112 (CAS 939981-39-2) is a selective small-molecule inhibitor of the interaction between the tumor suppressor protein p53 and its negative regulator MDM2 By blocking MDM2-p53 binding RG7112 releases and stabilizes p53 thereby enhancing the transcriptional activation of genes responsible for cell cycle arrest and apoptosis RG7112 preferentially inhibits proliferation in cancer cells harboring wild-type p53 exhibiting IC50 values ranging from 0 18 to 2 2 M whereas its efficacy diminishes significantly in p53-mutant cells RG7112 is used as a tool compound in biomedical research investigating p53-dependent antitumor mechanisms and pathways affecting hematopoiesis
Apexbio Technology LLC Rifaximin (Xifaxan) 80621-81-4 10mM (in 1mL DMSO)
Rifaximin (Xifaxan) a rifamycin derivative is a nonabsorbable antibiotic targeting bacterial RNA synthesis by binding to the -subunit of bacterial DNA-dependent RNA polymerase In vitro rifaximin also functions as an intestinal-specific agonist for human pregnane X receptor (PXR) modulating intestinal immune responses Rifaximin (EC50 20 M) activates human PXR reducing inflammatory cytokine expression induced by LPS in human colonic biopsies In animal models rifaximin alters intestinal expression of PXR-responsive genes relevant to drug metabolism and lipid homeostasis Clinically rifaximin has been utilized in research on hepatic encephalopathy and irritable bowel syndrome (IBS)
Apexbio Technology LLC IWR-1-endo 1127442-82-3 10mM (in 1mL DMSO)
IWR-1-endo (CAS 1127442-82-3) is a synthetic small-molecule antagonist of the Wnt/ -catenin signaling pathway It inhibits the activity of WNT1 2 and 3 ligands preventing downstream -catenin accumulation by stabilizing Axin-based degradation complexes and disrupting signaling events mediated via LRP6 and DVL2 Experimentally IWR-1-endo suppresses processes dependent on Wnt/ -catenin activity such as tissue regeneration and epithelial stem cell self-renewal demonstrated notably in zebrafish tailfin regeneration models Additionally it reduces abnormal proliferation induced by APC loss in cancer cell lines highlighting its relevance in oncogenesis research
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 500ML
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500ML
Apexbio Technology LLC 4μ8C 14003-96-4 10mM (in 1mL DMSO)
4 8C (CAS 14003-96-4) is a small molecule inhibitor targeting the RNase activity of inositol-requiring enzyme 1 alpha (IRE1 ) an important transmembrane serine/threonine kinase involved in the unfolded protein response (UPR) By selectively blocking IRE1-mediated RNase function 4 8C inhibits downstream UPR gene activation in cell lines exposed to hypoxia or endoplasmic reticulum (ER) stressors including HCT116 colon carcinoma and KP4 pancreatic cancer cells without affecting proliferation or clonogenic survival under these conditions Due to its selective action 4 8C serves as a valuable tool in research investigating ER stress pathways and their roles in cellular adaptation and disease pathology
Apexbio Technology LLC Empagliflozin (BI 10773) 864070-44-0 10mM (in 1mL DMSO)
Empagliflozin (BI 10773 CAS 864070-44-0) is a potent selective inhibitor targeting sodium-glucose cotransporter 2 (SGLT-2) a transmembrane protein primarily expressed in the kidneys and responsible for glucose reabsorption Empagliflozin inhibits SGLT-2 with an IC50 of 3 1 nM demonstrating high selectivity relative to related transporters (SGLT-1 4 5 and 6) In vitro studies using HK2 human proximal tubular cells showed that empagliflozin suppresses high glucose-induced pro-inflammatory signaling pathways including TLR4 NF- B AP-1 and IL-6 secretion Empagliflozin has been widely studied in diabetic animal models such as Zucker diabetic obese rats effectively reducing blood glucose and increasing urinary glucose excretion supporting its application in diabetes research
Apexbio Technology LLC Famprofazone 10mM (in 1mL DMSO)
A8431 is a small molecule that functions as a selective inhibitor of autophagy a conserved cellular pathway responsible for the lysosome-mediated degradation of intracellular components Acting primarily through interference with autophagosome formation or lysosomal fusion A8431 disrupts autophagic flux and thus influences cellular homeostasis and survival pathways It is widely utilized in biomedical research to dissect autophagy-mediated cellular mechanisms and has relevance in studies of cancer biology neurodegeneration and metabolic disorders where autophagy regulation is implicated
AdipoGen DAF-2T Solution 5 mM in DMSO
Chemical. CAS 261351-48-8. Formula C28H29N5O3. MW 483.6. Reference compound for the fluorescent nitric oxide NO probe DAR-2.
Thermo Scientific Production Chemicals and Services DOE AND INGALLS
NC3952589 DIMETHYL SULFOXIDE MULTI 190LT