Dimethyl Sulfoxide
Apexbio Technology LLC LY2874455(Synonyms: LY-2874455, LY 2874455, FGFR inhibitor LY2874455, Fibroblast growth factor receptor inhibitor LY2874455), 10mM (in 1mL DMSO), CAS: 1254473-64-7.
LY2874455 (CAS 1254473-64-7) is a small molecule inhibitor targeting fibroblast growth factor receptors (FGFRs) proteins functioning through ligand-induced receptor dimerization and tyrosine kinase activation By blocking FGFR phosphorylation and downstream signaling pathways LY2874455 inhibits proliferation and migration in FGFR-dependent cancer cell models LY2874455 shows inhibition of FGFR phosphorylation in FGFR1- FGFR2- and FGFR3-expressing cancer cell lines and xenografts demonstrating antitumor efficacy across various FGFR-driven tumor types It serves as a valuable tool molecule in oncology research investigating FGFR-mediated cancers
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitabl
Dimethyl sulfoxide (DMSO) is a polar organic solvent. DMSO activated by various electrophiles (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. Due to its higher stability it has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction.
Apexbio Technology LLC Reparixin 266359-83-5 10mM (in 1mL DMSO)
Reparixin (CAS 266359-83-5) is a noncompetitive allosteric inhibitor of chemokine receptors CXCR1 and CXCR2 which are seven-transmembrane G-protein coupled receptors involved notably in acute inflammatory responses Reparixin specifically disrupts CXCR1/2-mediated neutrophil recruitment and migration without affecting other receptor pathways In murine ischemia-reperfusion injury models Reparixin administration significantly inhibits neutrophil influx and associated inflammation-related tissue damage Thus Reparixin serves as a valuable research tool for investigating CXCR-dependent inflammatory mechanisms and evaluating therapeutic potentials in conditions such as acute lung injury and spinal cord damage
Apexbio Technology LLC EMD638683 1181770-72-8 10mM (in 1mL DMSO)
EMD638683 (CAS 1181770-72-8) is a selective inhibitor of serum- and glucocorticoid-inducible kinases (SGKs) including isoforms SGK1 SGK2 and SGK3 SGK1 regulates key cellular processes such as ion transport survival proliferation and responses to steroid hormones EMD638683 shows inhibitory activity against SGK1 SGK2 and SGK3 (IC50 3 M) significantly reducing SGK-dependent phosphorylation of NDRG1 in vitro It demonstrates limited off-target interactions inhibiting only MSK1 and PRK2 at 1 M while sparing numerous other kinases In cell models EMD638683 influences mitochondrial polarization and caspase activity exhibiting antitumor effects in colorectal tumor cells and antihypertensive activity in vivo
Apexbio Technology LLC Tianeptine sodium(Synonyms: Stablon, Coaxil, Tatinol, Tianeurax, Salymbra, Tianeptine Sodium Salt), 10mM (in 1mL DMSO), CAS: 30123-17-2.
Tianeptine sodium (CAS 30123-17-2) is a small molecule known to selectively facilitate serotonin (5-HT) uptake in both in vitro and in vivo experimental models It exhibits minimal affinity toward various neurotransmitter receptors including serotonin and dopamine receptors (IC 10 M) and does not affect the uptake mechanisms of noradrenaline or dopamine Due to its distinct serotonergic modulation tianeptine sodium is extensively used in neuroscience research particularly in studies investigating the molecular basis and therapeutic potential of antidepressants
Apexbio Technology LLC Brassinolide 72962-43-7 10mM (in 1mL DMSO)
Brassinolide (CAS 72962-43-7) is a naturally occurring steroidal plant growth regulator It influences various physiological processes in plants including stem elongation leaf differentiation flower formation and fruit development In vitro studies indicated that brassinolide induces apoptosis in human prostate cancer PC-3 cells characterized by increased caspase-3 activity and decreased Bcl-2 protein expression In animal models brassinolide reduced blood glucose levels in diabetic rats demonstrating non-dose-dependent hypoglycemic effects without observed toxicity Brassinolide is valuable in research related to cancer cell apoptosis and glucose metabolism regulation
Apexbio Technology LLC CO-1686 (AVL-301) 1374640-70-6 10mM (in 1mL DMSO)
CO-1686 (AVL-301 CAS 1374640-70-6) is an orally delivered irreversible small molecule inhibitor targeting mutated epidermal growth factor receptor (EGFR) It functions by forming a covalent bond at cysteine 797 in the ATP-binding domain of EGFR selectively inhibiting mutant variants such as L858R/T790M with reported IC50 values below 0 51 nM CO-1686 preferentially targets mutant EGFR over wild-type demonstrating approximately 22-fold selectivity Preclinical studies using non-small cell lung cancer (NSCLC) cell lines and xenograft models carrying EGFR mutations showed potent anti-proliferative and tumor regression effects Thus CO-1686 represents a valuable research tool in studying mutant EGFR-mediated oncogenesis
AdipoGen DAF-2T Solution 5 mM in DMSO
Chemical. CAS 261351-48-8. Formula C28H29N5O3. MW 483.6. Reference compound for the fluorescent nitric oxide NO probe DAR-2.
Apexbio Technology LLC PF-04217903(Synonyms: PF04217903, PF 04217903, PF-4217903, PF4217903, MET inhibitor PF-04217903), 10mM (in 1mL DMSO), CAS: 956905-27-4.
PF-04217903 (CAS 956905-27-4) is a selective ATP-competitive inhibitor targeting the receptor tyrosine kinase c-Met with a reported Ki value of 4 8 nM Aberrant activation or amplification of c-Met signaling contributes significantly to tumor cell proliferation angiogenesis and metastasis PF-04217903 exhibits high selectivity for c-Met over numerous other kinases and inhibits various c-Met mutants including R988C V1092I H1094R and T1010I In cellular studies using lines such as GTL-16 and H1993 PF-04217903 inhibits proliferation and induces apoptosis In vivo it effectively reduces c-Met phosphorylation and tumor growth suggesting potential as a research tool for investigating c-Met-related oncogenic pathways
Medchemexpress LLC Carbocysteine sulfoxide | 5439-87-2 | MFCD21364079 | 99.0% | 195.19 | C5H9NO5S | 25 MG
Carbocysteine sulfoxide is a small-molecule drug intermediate and a reported impurity of carbocisteine supplied for research and analytical use. It is intended for impurity profiling, method development, and related analytical applications. The compound is identified by CAS number 5439-87-2 and has formula C5H9NO5S and a molecular weight of 195.19 g/mol. Storage and handling recommendations are provided in the product certificate of analysis.
Medchemexpress LLC Ocedurenone 10 mM 1 mL in DMSOSolid Solvent
Ocedurenone 10 mM*1 mL in DMSOSolid + Solvent